Determination of acetochlor by UPLC-MS 3 in cells and its application to a cellular pharmacokinetic study

• Published in: Analytical biochemistry Vol. 688; p. 115476
• Main Authors: Lu, Di, Zheng, Xinyue, Xue, Hongyu, You, Jiansong, Yin, Lei, Shi, Meiyun
• Format: Journal Article
• Language: English
• Published: United States 01.05.2024
• Subjects: UPLC-MS; Acetochlor; Cellular pharmacokinetics; Herbicide

The aim of this work was to develop a fast, simple, and reliable UPLC-MS method for the sensitive detection of acetochlor in biological samples. In MS mode, the ion transition m/z 270.1 → 224.1→148.1 was chosen for quantification with butachlor as the internal standard. In the UPLC system, separatio...