Phytochemicals from the stem bark of Calophyllum havilandii P.F. Stevens and their biological activities

The genus Calophyllum from the family Calophyllaceae has been extensively investigated in the past due to its rich source of bioactive phenolics such as coumarins, chromanones, and xanthones. In this study, phytochemical investigation on the stem bark of Calophyllum havilandii has afforded a new 4-p...

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Published inChemistry & biodiversity p. e202301936
Main Authors Zailan, Ahmad Alif Danial, Karunakaran, Thiruventhan, Santhanam, Rameshkumar, Yaakop, Amira Suriaty, Mohan, Sivakumar, Abu Bakar, Mohamad Hafizi, Mian, Vivien Jong Yi
Format Journal Article
LanguageEnglish
Published Switzerland 24.01.2024
Subjects
anti-bacillus
Calophyllum
Coumarin
cytotoxicity
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Summary:The genus Calophyllum from the family Calophyllaceae has been extensively investigated in the past due to its rich source of bioactive phenolics such as coumarins, chromanones, and xanthones. In this study, phytochemical investigation on the stem bark of Calophyllum havilandii has afforded a new 4-propyldihydrocoumarin derivative, havilarin (1) together with calolongic acid (2), caloteysmannic acid (3), isocalolongic acid (4), euxanthone (5), and β-sitosterol (6). The chemical structure of compound 1 was elucidated and established based on detailed spectroscopic techniques, including MS, IR, UV, 1D and 2D NMR. The results of anti-bacillus study indicated that the chloroform extract showed promising activities with MIC value ranging between 0.5 to 1 μg/mL on selected bacillus strains. Besides, the plant extracts and compounds 1-4 were assessed for their cytotoxicity potential on HL-7702 cell line. All the tested plant extracts and respective chemical constituents displayed non-cytotoxic activity on HL-7702 cell line.
ISSN:1612-1880