H 2 S serves as the immunoregulatory essence of apoptotic cell death

Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H S) release during apoptosi...

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Bibliographic Details
Published inCell metabolism Vol. 36; no. 1; p. 3
Main Authors Hine, Christopher, Ponti, András K, Cáliz-Molina, María Ángeles, Martín-Montalvo, Alejandro
Format Journal Article
LanguageEnglish
Published United States 02.01.2024
Subjects
Apoptosis
Homeostasis
Hydrogen Sulfide - metabolism
Hydrogen Sulfide - pharmacology
Proteomics
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Summary:Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.
ISSN:1932-7420