Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in Multicenter 123 I-mIBG Phantom Studies

: Cross-calibration of I-labeled -iodobenzylguanidine ( IBG) myocardial-derived indices is essential to extrapolate findings from several clinical centers. Here, we conducted a phantom study to generate conversion coefficients for the calibration of heart-to-mediastinum ratios and compare them betwe...

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Bibliographic Details
Published inAnnals of nuclear cardiology Vol. 9; no. 1; p. 54
Main Authors Okuda, Koichi, Nakajima, Kenichi, Hung, Guang-Uei, Wu, Hao-Ting, Verschure, Derk O, Verberne, Hein J, Kitamura, Chiemi
Format Journal Article
LanguageEnglish
Published Japan 2023
Subjects
123I-mIBG
Phantom
Collimator
Calibration
Heart-to-mediastinum ratio
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Summary:: Cross-calibration of I-labeled -iodobenzylguanidine ( IBG) myocardial-derived indices is essential to extrapolate findings from several clinical centers. Here, we conducted a phantom study to generate conversion coefficients for the calibration of heart-to-mediastinum ratios and compare them between Taiwan and Europe. : We used an acrylic phantom dedicated to I- IBG planar imaging to calculate the conversion coefficients of 136 phantom images derived from 36 Taiwanese institutions. A European phantom image database including 191 images from 27 institutions was used. Conversion coefficients were categorized into five collimator types: low-energy (LE) high-resolution (LEHR), LE general-purpose (LEGP), extended LEGP (ELEGP), medium-energy (ME) GP (MEGP), and ME low-penetration (MELP) collimators. : The conversion coefficients were 0.53 ± 0.039, 0.59 ± 0.032, 0.79 ± 0.032, 0.96 ± 0.038, and 0.99 ± 0.050 for LEHR, LEGP, ELEGP, MEGP, and MELP collimators, respectively. The Taiwanese and European conversion coefficients for the LEHR, LEGP, and MELP collimators did not significantly differ. The coefficient of variation was slightly higher for the Taiwanese than the European conversion coefficients (3.7%-7.5% 2.3%-5.6%). : We calculated conversion coefficients for various types of collimators used in Taiwan using a I- IBG phantom. In general, the Taiwanese and European conversion coefficients were comparable. These findings further corroborated and highlighted the need for I- IBG standardization using the phantom-determined conversion coefficients.
ISSN:2424-1741