Anti-inflammatory Effects of Compounds Extracted from Marine Sponge s: A Systematic Review

Previous studies have experimentally validated and reported that chemical constituents of marine sponges are a source of natural anti-inflammatory substances with the biotechnological potential to develop novel drugs. Therefore, the aim of this study was to perform a systematic review to provide an...

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Published inAnti-inflammatory & anti-allergy agents in medicinal chemistry Vol. 22; no. 3; p. 164
Main Authors Magri, Angela Maria Paiva, Avanzi, Ingrid Regina, Vila, Guilherme Trindade, Granito, Renata Neves, Estadella, Débora, Jimenez, Paula Christine, Ribeiro, Alessandra Mussi, Rennó, Ana Claudia Muniz
Format Journal Article
LanguageEnglish
Published United Arab Emirates 2023
Subjects
inflammatory pathways
pathogens
pro-inflammatory mediators
Marine natural products
health
anti-inflammatory bioactives
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Summary:Previous studies have experimentally validated and reported that chemical constituents of marine sponges are a source of natural anti-inflammatory substances with the biotechnological potential to develop novel drugs. Therefore, the aim of this study was to perform a systematic review to provide an overview of the anti-inflammatory substances isolated from marine sponges with therapeutic potential. This systematic review was performed on the Embase, PubMed, Scopus and Web of Science electronic databases. In total, 613 were found, but 340 duplicate studies were excluded, only 100 manuscripts were eligible, and 83 were included. The results were based on and assays, and the anti-inflammatory effects of 251 bioactive compounds extracted from marine sponges were investigated. Their anti-inflammatory activities include inhibition of pro-inflammatory mediators, such as tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), nitrite or nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 1β (IL-1β), prostaglandin E2 (PGE2), phospholipase A2 (PLA2), nuclear transcription factor-kappa B (NF-κB), leukotriene B4 (LTB4), cyclooxygenase- 1 (COX-1), and superoxide radicals. In conclusion, data suggest (approximately 98% of articles) that substances obtained from marine sponges may be promising for the development of novel anti-inflammatory drugs for the treatment of different pathological conditions.
ISSN:1875-614X