Immunologic memory for Staphylococcus studied by adoptive transfer

The basic regularities of the formation and realization of immunological memory to staphylococcal corpuscular antigen were studied in adoptive transfer experiments on CBA mice. The capacity of spleen cells for generating anamnestic response to staphylococci in the body of irradiated syngeneic recipi...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 10; p. 93
Main Authors Liashchenko, K P, Golovanova, T A, Bobrovnik, S A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1986
Subjects
Animals
Antibodies, Bacterial - analysis
Antibody-Producing Cells - immunology
Antigens, Bacterial - immunology
Immunization
Immunization, Passive
Immunologic Memory
Mice
Mice, Inbred CBA
Spleen - immunology
Staphylococcus aureus - immunology
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Summary:The basic regularities of the formation and realization of immunological memory to staphylococcal corpuscular antigen were studied in adoptive transfer experiments on CBA mice. The capacity of spleen cells for generating anamnestic response to staphylococci in the body of irradiated syngeneic recipients appeared on day 3 after the immunization of donors. The formation of immunological memory to staphylococci in mice was shown to be directly related to the dose of the antigen. The study also revealed that intact splenocytes did not suppress the realization of immunological memory to staphylococci in the system of adoptive transfer. The conclusion of the absence of the "isogeneic barrier" for memory cells specific to staphylococcal corpuscular antigen was made.
ISSN:0372-9311