C 60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke

The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C -Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of applic...

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Published inNanomedicine p. 102698
Main Authors Kukaliia, Oleg N, Ageev, Sergei V, Petrov, Andrey V, Kirik, Olga V, Korzhevskii, Dmitrii E, Meshcheriakov, Anatolii A, Iakovleva, Anastasiia A, Poliakova, Liudmila S, Novikova, Tatiana A, Kolpakova, Mariia E, Vlasov, Timur D, Molchanov, Oleg E, Maistrenko, Dmitriy N, Murin, Igor V, Sharoyko, Vladimir V, Semenov, Konstantin N
Format Journal Article
LanguageEnglish
Published United States 26.07.2023
Subjects
Fullerene adduct
Ischemia
Antioxidant activity
Haemocompatibility
Histology
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Summary:The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C -Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C -Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C -Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.
ISSN:1549-9642