Myocardial injury in patients of the intensive care unit of various age groups.

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 36; no. 2; p. 206
• Main Authors: Alferov, S P, Kabanov, M Y, Kurydkashina, A G, Gulnova, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2023
• Subjects: Aged; Humans; Intensive Care Units; Multiple Organ Failure; Prognosis; Risk Factors; Troponin; mechanical lung ventilation; multiple organ failure; troponin; coronary insufficiency; echocardiography; vasopressor support; coronary angiography; risk of adverse events
• ISSN: 1561-9125

The article deals with the problem of myocardial damage of various genesis in patients of the intensive care unit and intensive care unit of various age groups. The study included patients with various pathologies with significant manifestations of multiple organ failure and high risks of adverse outcomes. Parametric (Student's t-test) and nonparametric (Mann-Whitney U-test, Pearson's χ2 criterion) statistical methods were used to analyze the severity of the inflammatory response, organ dysfunction, and the need for replacement therapy, in particular ventilator and vasopressor support in patients of different age groups. The frequency of myocardial damage was studied on the basis of an increase in cardiac troponin in patients of the intensive care unit. A comparison of the increase in troponin with morphological changes of the heart was carried out based on the analysis of ECHO, coronary angiography and sectional material. The role of cardiac troponin in the prognosis of adverse events in patients of different ages was analyzed. As a result of the study, it was found that the degree of severity of organ dysfunction, inflammatory response and the need for replacement therapy significantly prevail in elderly patients, as well as the phenomenon of myocardial damage. The main proportion of myocardial lesions was nonspecific. At the same time, the very fact of an increase in cardiac troponin in patients of the intensive care unit is an independent risk factor for adverse outcomes, regardless of the age of the patients.