Molecular epidemiology of microsatellite instability/mismatch repair deficiency in our institute - methodical aspects

Molecular epidemiology of mismatch repair deficiency (dMMR)/microsatellite instability (MSI) are different in various ethnic groups; accordingly, our aim was to test this in a large single-center Hungarian cancer patient cohort. We have found that dMMR/MSI incidence correlates well with TCGA data in...

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Published inMagyar onkologia Vol. 67; no. 2; p. 147
Main Authors Nádorvári, Lilla Maja, Kiss, András, Barbai, Tamás, Kulka, Janina, Rásó, Erzsébet, Tímár, József
Format Journal Article
LanguageHungarian
Published Hungary 13.06.2023
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Summary:Molecular epidemiology of mismatch repair deficiency (dMMR)/microsatellite instability (MSI) are different in various ethnic groups; accordingly, our aim was to test this in a large single-center Hungarian cancer patient cohort. We have found that dMMR/MSI incidence correlates well with TCGA data in case of colorectal, gastric and endometrial cancers. We have also observed that immunohistochemistry- based dMMR incidences are higher as compared to MSI. We suggest that the testing guidelines must be fine-tuned for immune-oncology indications. Nádorvári ML, Kiss A, Barbai T, Rásó E, Tímár J. Molecular epidemiology of mismatch repair deficiency, microsatellite instability in a large single diagnostic center cancer cohort.
ISSN:2060-0399