H 2 O 2 /O 2 self-supply and Ca 2+ overloading MOF-based nanoplatform for cascade-amplified chemodynamic and photodynamic therapy

• Published in: Frontiers in bioengineering and biotechnology Vol. 11; p. 1196839
• Main Authors: Liang, Yujia, Cai, Zhengmin, Tang, Yamei, Su, Chenglin, Xie, Liye, Li, Yan, Liang, Xinqiang
• Format: Journal Article
• Language: English
• Published: Switzerland 2023
• Subjects: chemodynamic therapy; photodynamic therapy; H2O2/O2 self-supply; MOFs; CaO2
• ISSN: 2296-4185; 2296-4185

Reactive oxygen species (ROS)-mediated therapies have typically been considered as noninvasive tumor treatments owing to their high selectivity and efficiency. However, the harsh tumor microenvironment severely impairs their efficiency. Herein, the biodegradable Cu-doped zeolitic imidazolate framework-8 (ZIF-8) was synthesized for loading photosensitizer Chlorin e6 (Ce6) and CaO nanoparticles, followed by surface decoration by hyaluronic acid (HA), obtaining HA/CaO -Ce6@Cu-ZIF nano platform. Once HA/CaO -Ce6@Cu-ZIF targets tumor sites, the degradation of Ce6 and CaO release from the HA/CaO -Ce6@Cu-ZIF in response to the acid environment, while the Cu active sites on Cu-ZIF are exposed. The released CaO decompose to generate hydrogen peroxide (H O ) and oxygen (O ), which alleviate the insufficiency of intracellular H O and hypoxia in tumor microenvironment (TME), effectively enhancing the production of hydroxyl radical (•OH) and singlet oxygen ( O ) in Cu -mediated chemodynamic therapy (CDT) and Ce6-induced photodynamic therapy (PDT), respectively. Importantly, Ca originating from CaO could further enhance oxidative stress and result in mitochondrial dysfunction induced by Ca overloading. Thus, the H O /O self-supplying and Ca overloading ZIF-based nanoplatform for cascade-amplified CDT/PDT synergistic strategy is promising for highly efficient anticancer therapy.