A multifunctionally reversible detector: Photoacoustic and dual-channel fluorescence sensing for SO 2 /H 2 O 2

In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO /H O content in mitochondria and lipid droplets were...

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Bibliographic Details
Published inAnalytica chimica acta Vol. 1263; p. 341181
Main Authors Zhu, Yicai, Wang, Junjun, Ni, Yingyong, Rao, Qingpeng, Zhu, Xiaojiao, Yu, Jianhua, Wang, Sen, Zhou, Hongping
Format Journal Article
LanguageEnglish
Published Netherlands 04.07.2023
Subjects
Electrons
Fluorescence
Hydrogen Peroxide
Lipid Droplets
Mitochondria
Near-infrared absorption
Double-organelle
SO/HO redox homeostasis
Dual-mode imaging
Donor optimization
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Summary:In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO /H O content in mitochondria and lipid droplets were observed through red/green channels respectively, which was due to the reaction between benzopyrylium fragment of T1 and SO /H O to achieve red/green fluorescence conversion. Additionally, T1 was endowed with photoacoustic properties deriving from NIR-I absorption to reversibly monitor SO /H O in vivo. This work was significant for more accurately deciphering the physiological and pathological processes in living organisms.
ISSN:1873-4324