Vector Competence for Zika Virus Changes Depending on the Aedes aegypti 's Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City

Zika virus (ZIKV) is transmitted to humans by the infectious bite of mosquitoes such as . In a city, the population control of mosquitoes is carried out according to alerts generated by different districts via the analysis of the mosquito index. However, we do not know whether, besides mosquito abun...

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Published inViruses Vol. 15; no. 3
Main Authors da Costa Paz, Andréia, Chaves, Bárbara Aparecida, Godoy, Raquel Soares Maia, Coelho, Deilane Ferreira, Vieira Júnior, Ademir Bentes, Alencar, Rodrigo Maciel, Alcântara, João Arthur, Félix, Luiza Dos Santos, Oliveira, Cinthia Catharina Azevedo, Monteiro, Wuelton Marcelo, Lacerda, Marcus Vinicius Guimarães, Secundino, Nágila Francinete Costa, Pimenta, Paulo Filemon Paolucci
Format Journal Article
LanguageEnglish
Published Switzerland 17.03.2023
Subjects
Aedes
Animals
Brazil - epidemiology
Humans
Mosquito Vectors
Saliva
Zika Virus - genetics
Zika Virus Infection
Brazil
infection rate
disseminated infection rate
Zika virus
vector competence
transmission efficiency
field mosquito population
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Summary:Zika virus (ZIKV) is transmitted to humans by the infectious bite of mosquitoes such as . In a city, the population control of mosquitoes is carried out according to alerts generated by different districts via the analysis of the mosquito index. However, we do not know whether, besides mosquito abundance, the susceptibility of mosquitoes could also diverge among districts and thus impact the dissemination and transmission of arboviruses. After a viremic blood meal, the virus must infect the midgut, disseminate to tissues, and reach the salivary gland to be transmitted to a vertebrate host. This study evaluated the patterns of ZIKV infection in the field populations of a city. The disseminated infection rate, viral transmission rate, and transmission efficiency were measured using quantitative PCR at 14 days post-infection. The results showed that all populations had individuals susceptible to ZIKV infection and able to transmit the virus. The infection parameters showed that the geographical area of origin of the influences its vector competence for ZIKV transmission.
ISSN:1999-4915