Hyaluronic acid hydrolysis using vacuum ultraviolet TiO 2 photocatalysis combined with an oxygen nanobubble system

Advanced technologies for producing high-quality low molecular weight hyaluronic acid (LMW-HA) are required from the perspective of cost-efficiency and biosafety. Here, we report a new LMW-HA production system from high molecular weight HA (HMW-HA) using vacuum ultraviolet TiO photocatalysis with an...

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Bibliographic Details
Published inCarbohydrate polymers Vol. 299; p. 120178
Main Authors Cho, Sung Yeon, Lee, Seokjae, Yang, Kyungjik, Kim, Young Min, Choe, Deokyeong, Kim, Jeong Un, Lee, Dong-Un, Park, Jiyong, Roh, Young Hoon
Format Journal Article
LanguageEnglish
Published England 01.01.2023
Subjects
Endotoxins
Hyaluronic Acid
Hydrolysis
Oxygen
Vacuum
UV-TiO photocatalysis
Hyaluronic acid hydrolysis
Antioxidant activity
Endotoxin
Nanobubble
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Summary:Advanced technologies for producing high-quality low molecular weight hyaluronic acid (LMW-HA) are required from the perspective of cost-efficiency and biosafety. Here, we report a new LMW-HA production system from high molecular weight HA (HMW-HA) using vacuum ultraviolet TiO photocatalysis with an oxygen nanobubble system (VUV-TP-NB). The VUV-TP-NB treatment for 3 h resulted in a satisfactory LMW-HA (approximately 50 kDa measured by GPC) yield with a low endotoxin level. Further, there were no inherent structural changes in the LMW-HA during the oxidative degradation process. Compared with conventional acid and enzyme hydrolysis methods, VUV-TP-NB showed similar degradation degree with viscosity though reduced process time by at least 8-fold. In terms of endotoxin and antioxidant effects, degradation using VUV-TP-NB demonstrated the lowest endotoxin level (0.21 EU/mL) and highest radical scavenging activity. This nanobubble-based photocatalysis system can thus be used to produce biosafe LMW-HA cost-effectively for food, medical, and cosmetics applications.
ISSN:1879-1344