Delineating genotypes and phenotypes of individual cells from long-read single cell transcriptomes

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Shiau, Cheng-Kai, Lu, Lina, Kieser, Rachel, Fukumura, Kazutaka, Pan, Timothy, Lin, Hsiao-Yun, Yang, Jie, Tong, Eric L, Lee, GaHyun, Yan, Yuanqing, Huse, Jason T, Gao, Ruli
• Format: Journal Article
• Language: English
• Published: United States 03.02.2023

Single-cell nanopore sequencing of full-length mRNAs (scNanoRNAseq) is transforming singlecell multi-omics studies. However, challenges include computational complexity and dependence on short-read curation. To address this, we developed a comprehensive toolkit, scNanoGPS to calculate same-cell geno...