Senescence-associated secretory phenotype and inflammaging: the role in cardiovascular diseases.

Senescent cells take part into development the age-related diseases by formation the SASP: senescence-associated secretory phenotype. SASP is characterized by synthesis of signal molecules include proinflammatory cytokines. SASP promotes the inflammaging - chronic, low-grade, subclinical inflammator...

Full description

Saved in:
Bibliographic Details
Published inAdvances in gerontology = Uspekhi gerontologii Vol. 35; no. 5; p. 737
Main Authors Savitskiy, D V, Linkova, N S, Diatlova, A S, Kvetnaia, T V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2022
Subjects
inflammaging
cardio-vascular diseases
aging
SASP
Online AccessGet more information

Cover

More Information
Summary:Senescent cells take part into development the age-related diseases by formation the SASP: senescence-associated secretory phenotype. SASP is characterized by synthesis of signal molecules include proinflammatory cytokines. SASP promotes the inflammaging - chronic, low-grade, subclinical inflammatory process, that is the one of cardio-vascular diseases risk factor in older age-groups. In the review we describe the key SASP molecules of cardiomyocytes, endotheliocytes and vascular smooth muscle cells and its role in the pathogenesis of age-associated cardiovascular diseases.
ISSN:1561-9125