Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on 18 F-FDG-PET/CT

Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the...

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Bibliographic Details
Published inFrontiers in medicine Vol. 9; p. 1078560
Main Authors Amrane, Karim, Le Meur, Coline, Thuillier, Philippe, Alemany, Pierre, Niel, Clémence, Renault, David, Abgral, Ronan
Format Journal Article
LanguageEnglish
Published Switzerland 2022
Subjects
pembrolizumab
eosinophilic fasciitis
NSCLC
18F-FDG-PET/CT
ICI
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Summary:Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.
ISSN:2296-858X
2296-858X