The Role of N 6 -Methyladenosine in Inflammatory Diseases

N -Methyladenosine (m A) is the most abundant epigenetic RNA modification in eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells through changes in the activity of writers, erasers, and readers and ultimately affecting human life or disease processes. Inflammat...

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Published inOxidative medicine and cellular longevity Vol. 2022; p. 9744771
Main Authors Xu, Haojun, Lin, Changjie, Yang, Jinghan, Chen, Xi, Chen, Yingyu, Chen, Jianguo, Guo, Aizhen, Hu, Changmin
Format Journal Article
LanguageEnglish
Published United States 2022
Subjects
Adenosine
Epigenesis, Genetic
Humans
Neoplasms - metabolism
RNA - metabolism
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Summary:N -Methyladenosine (m A) is the most abundant epigenetic RNA modification in eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells through changes in the activity of writers, erasers, and readers and ultimately affecting human life or disease processes. Inflammation is a response to infection and injury in various diseases and has therefore attracted significant attention. Currently, extensive evidence indicates that m A plays an essential role in inflammation. In this review, we focus on the mechanisms of m A in inflammatory autoimmune diseases, metabolic disorder, cardio-cerebrovascular diseases, cancer, and pathogen-induced inflammation, as well as its possible role as targets for clinical diagnosis and treatment.
ISSN:1942-0994