Influence of the immunomodulatory drug stimforte on the humoral immune response in the experimental herpes virus infection

In the study of the immunostimulation preparation Stimforte activity using the model of the experimental herpes virus infection BALB/c, mice has shown that sera from mice treated with the drug on the 4th and 7th day after infection possessed a 3 times greater capability of specifically binding to th...

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Published inVoprosy virusologii Vol. 61; no. 4; p. 172
Main Authors Maldov, D G, Andronova, V L, Balakina, A A, Ilyichev, A V, Galegov, G A
Format Journal Article
LanguageEnglish
Published Russia (Federation) 28.08.2016
Subjects
herpes simplex virus
immunostimulator
inhibition of viral replication
Stimforte
humoral response
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Summary:In the study of the immunostimulation preparation Stimforte activity using the model of the experimental herpes virus infection BALB/c, mice has shown that sera from mice treated with the drug on the 4th and 7th day after infection possessed a 3 times greater capability of specifically binding to the culture of HSV-1 (on cells Vero) according to dot blot analysis, as compared with intact infected mice sera obtained at the same time. It was also shown that these sera had a 5 times higher index of neutralization. On the basis of Western blots, it was detected that antibodies from sera of mice treated with Stimforte contacted the glycoproteins gB and gC of HSV-1 significantly better. Thus, Stimforte stimulates one of the strongest modulatory effects on the immune memory and is a promising drug for the treatment of chronic viral diseases.
ISSN:2411-2097