Comparative analysis of genetic variants of the HIV-1 circulating in the Irkutsk region in 1999 and 2012

The pol and env genome regions of the HIV-1 genetic variants circulating in the irkutsk region of russia in 1999 and 2012 were compared. The results of this work showed the dominance of the HIV-1 subtype a IDU-A genetic variant (100%) in this region. No primary resistance mutations in the pol gene i...

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Bibliographic Details
Published inVoprosy virusologii Vol. 61; no. 3; p. 112
Main Authors Lebedev, A V, Neshumaev, D A, Kazennova, E V, Lapovok, I A, Laga, V Y, Tumanov, A S, Glushchenko, N V, Plotnikova, Y K, Ponomareva, O A, Yarygina, E I, Bobkova, M R
Format Journal Article
LanguageRussian
Published Russia (Federation) 28.06.2016
Subjects
HIV-1
IDU-A variant
drug resistance mutations
tropism
genetic distance
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Summary:The pol and env genome regions of the HIV-1 genetic variants circulating in the irkutsk region of russia in 1999 and 2012 were compared. The results of this work showed the dominance of the HIV-1 subtype a IDU-A genetic variant (100%) in this region. No primary resistance mutations in the pol gene in the treatment-naive patients were found. The heterogeneity of the viral population was found to be significantly increased based on the pol and env analysis among HIV-variants isolated in 2012 (12.88% and 2.16%) from the intravenous drug users as compared to HIV-variants that caused the outbreak of the HIV infection in 1999 (1.64% and 0.47%). In addition, the comparison of genetic distances of the pol and env gene sequences in the viruses isolated in 2012 from the HIV-positive persons infected through heterosexual intercourse and intravenous drug use demonstrated that the transmission route influenced the variability of the virus population. Among the viruses of IDU-A variant circulating in the area in 2012 the prevalence of X4-tropic variants was 24.7%.
ISSN:2411-2097