Biological function of selenoprotein Iodothyronine deiodinase and its expression in osteoarthritis

Objective Iodothyronine deiodinases (DIOs) are important selenoprotein that play a key role in the bone and joint diseases.Osteoarthritis (OA) is the most prevalent joint disease especially in elders. This bioinformatic analysis was performed to explore the role of DIOs in OA pathogenesis. Methods T...

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Bibliographic Details
Published inChinese medical sciences journal
Main Authors Ren, Xiao-Mei, Zhang, Li, Xin, Bao, Liu, Qi-Ling, Qian, Wen-Wen, Zhang, Rong-Qiang
Format Journal Article
LanguageEnglish
Published China 30.05.2022
Subjects
selenoprotein
osteoarthritis
iodothyronine deiodinase
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Summary:Objective Iodothyronine deiodinases (DIOs) are important selenoprotein that play a key role in the bone and joint diseases.Osteoarthritis (OA) is the most prevalent joint disease especially in elders. This bioinformatic analysis was performed to explore the role of DIOs in OA pathogenesis. Methods The biological functions of selenoprotein DIOs were analyzed by bioinformatic techniques, including GenCLip 3.0, Database for Annotation, Visualization and Integrated Discovery (DAVID), STRING, Cytoscape, and Network Analyst. The expression of DIOs in the healthy individuals and OA patients was determined by mining OA-related microarray data in the gene expression omnibus (GEO) database of National Center for Biotechnology Information (NCBI) and performing a Meta-analysis of the data with Review Manager 5.3. Results The result showed that (1) cluster analysis revealed that the function of the DIOs was associated with the thyroid hormones receptor and iodothyronine; (2) GO analysis showed that DIOs were mainly involved in biological processes, such as ethanol metabolism and phenol-containing compound metabolism and (3) primarily involved in the cytochrome P450 metabolism of exogenous organisms and thyroid hormone signaling; (4) was the core node of the PPI network; (5) miRNAs and thyroid hormones have some iterations with and ; (6) Meta-analysis showed that expression was significantly up-regulated in OA patients ( = 0.31, 95% 0.03, 0.59, = 0.03). Conclusions The main biological functions of DIOs were closely associated with the regulation of thyroid hormone. And the up-regulated expression of may play crucial impact in the occurrence of OA.
ISSN:1001-9294