Patient-Reported Outcomes Measures in Perianal Fistulizing Crohn's Disease

Perianal fistulizing Crohn's disease (PFCD) is a disabling complication of Crohn's disease (CD) that can significantly impact on patients' quality of life (QoL) and often requires multidisciplinary care. Clinical trials assessing the efficacy of medical and surgical interventions for...

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Bibliographic Details
Published inReviews on recent clinical trials
Main Authors Queiroz, Natália Sousa Freitas, Garcia, Karoline Soares, Miranda, Eron Fabio, Kotze, Paulo Gustavo
Format Journal Article
LanguageEnglish
Published United Arab Emirates 25.04.2022
Subjects
Crohn’s Disease
Magnetic Resonance Imaging
Rectal Fistula
Quality of Life
Fistula
Patient Reported Outcome Measures
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Summary:Perianal fistulizing Crohn's disease (PFCD) is a disabling complication of Crohn's disease (CD) that can significantly impact on patients' quality of life (QoL) and often requires multidisciplinary care. Clinical trials assessing the efficacy of medical and surgical interventions for fistulas usually evaluate outcomes such as closure of fistula tracts or radiologic healing. However, these traditional outcome assessments fail in capturing the impact of the disease from patients' perspectives. In this context, regulatory authorities have increasingly encouraged the inclusion of validated patient-reported outcomes (PRO) that assess disease activity and reveal how a patient functions and feels. This recent trend towards patient-centered care aims to ensure that improvements in efficacy outcomes are accompanied by meaningful benefits to patients. The aim of this review is to discuss currently available PRO measures (PROMS) for the assessment of PFCD to provide to physicians appropriate tools aiming to optimize patient care and disseminate the use of these instruments in clinical practice.
ISSN:1876-1038