Effect of the adrenomimetics noradrenaline and mezaton on gastric secretion clinically and experimentally

Chronic tests on dogs with fistulas in the fundal portion of the stomach and polychlorvinyl catheters implanted in the jugular vein brought evidence that infusion of norepinephrine or mesaton in a dose of 0.003-0.004 mg/kg for 1 1/2 and more hours inhibited the gastric secretion stimulated with carb...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 42; no. 2; p. 123
Main Authors Korshak, A L, Tsimmerman, Ia S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1979
Subjects
Animals
Carbachol - antagonists & inhibitors
Dogs
Duodenal Ulcer - physiopathology
Epinephrine - pharmacology
Gastric Juice - secretion
Histamine H1 Antagonists
Peptic Ulcer - physiopathology
Phenylephrine - pharmacology
Stomach Ulcer - physiopathology
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Summary:Chronic tests on dogs with fistulas in the fundal portion of the stomach and polychlorvinyl catheters implanted in the jugular vein brought evidence that infusion of norepinephrine or mesaton in a dose of 0.003-0.004 mg/kg for 1 1/2 and more hours inhibited the gastric secretion stimulated with carbocholine and histamine. In patients with duodenal and gastric localization of the ulcer an intramuscular injection of mesaton (10 mg) had no essential effect on the main characteristics of the basal gastric secretion.
ISSN:0014-8318