Predictive values of serum 8-hydroxydeoxyguanosine on disease progression and prognosis of patients with sepsis

To investigate the values of serum 8-hydroxydeoxyguanosine (8-OHdG) in predicting disease progression and prognosis of patients with sepsis. The prospective observational research methods were used. A total of 124 patients with sepsis who met the inclusion criteria were admitted to the Department of...

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Published inZhonghua shao shang yu chuang mian xiu fu za zhi Vol. 38; no. 3; p. 207
Main Authors Chen, X R, Jiang, D W, Tang, Y H, Xu, C, Zhi, S C, Hong, G L, Lu, Z Q, Zhao, G J
Format Journal Article
LanguageChinese
Published China 20.03.2022
Subjects
8-Hydroxy-2'-Deoxyguanosine
Aged
Disease Progression
Female
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
ROC Curve
Sepsis
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Summary:To investigate the values of serum 8-hydroxydeoxyguanosine (8-OHdG) in predicting disease progression and prognosis of patients with sepsis. The prospective observational research methods were used. A total of 124 patients with sepsis who met the inclusion criteria were admitted to the Department of Emergency of the First Affiliated Hospital of Wenzhou Medical University from April 2015 to July 2016, including 79 males and 45 females, aged (62±15) years. The sepsis-related organ failure assessment (SOFA) scores of all patients on admission and on the second day of admission and their difference (ΔSOFA) were calculated. The patients were divided into non-progression group with ΔSOFA score <2 ( =101) and progression group with ΔSOFA score ≥2 ( =23), and according to the survival during hospitalization, the patients were divided into survival group ( =85) and death group ( =39). Data of patients between non-progression group and progression group, survival group and death group were compared, including the gende
ISSN:2097-1109