A Novel Yolk-Shell Fe 3 O 4 @ Mesoporous Carbon Nanoparticle as an Effective Tumor-Targeting Nanocarrier for Improvement of Chemotherapy and Photothermal Therapy

Owing to their good stability and high photothermal conversion efficiency, the development of carbon-based nanoparticles has been intensively investigated, while the limitation of unsatisfactory cellular internalization impedes their further clinical application. Herein, we report a novel strategy f...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 23; no. 3
Main Authors Tian, Haina, Zhang, Ruifeng, Li, Jiaqi, Huang, Cailin, Sun, Wen, Hou, Zhenqing, Wang, Peiyuan
Format Journal Article
LanguageEnglish
Published Switzerland 30.01.2022
Subjects
Animals
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - therapy
Carbon - chemistry
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
Combined Modality Therapy
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Female
Magnetic Iron Oxide Nanoparticles - chemistry
Mice
Nanostructures
Particle Size
Photothermal Therapy
Treatment Outcome
Xenograft Model Antitumor Assays
Fe3O4
yolk–shell
MRI
photothermal therapy
mesoporous carbon
chemotherapy
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Summary:Owing to their good stability and high photothermal conversion efficiency, the development of carbon-based nanoparticles has been intensively investigated, while the limitation of unsatisfactory cellular internalization impedes their further clinical application. Herein, we report a novel strategy for fabrication of Fe O yolk-shell mesoporous carbon nanocarriers (Fe O @hmC) with monodispersity and uniform size, which presented significantly higher cell membrane adsorption and cellular uptake properties in comparison with common solid silica-supported mesoporous carbon nanoparticles with core-shell structure. Moreover, the MRI performance of this novel Fe-based nanoparticle could facilitate precise tumor diagnosis. More importantly, after DOX loading (Fe O @hmC-DOX), owing to synergistic effect of chemo-phototherapy, this therapeutic agent exhibited predominant tumor cell ablation capability under 808 nm NIR laser irradiation, both in vitro and in vivo. Our work has laid a solid foundation for therapeutics with hollowed carbon shell for solid tumor diagnosis and therapy in clinical trials.
ISSN:1422-0067