Characterising 18 F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging

F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of F-fluciclovine in breast cancer and assessed differences in tracer kinetics an...

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Bibliographic Details
Published inBritish journal of cancer Vol. 126; no. 4; p. 598
Main Authors Scott, N P, Teoh, E J, Flight, H, Jones, B E, Niederer, J, Mustata, L, MacLean, G M, Roy, P G, Remoundos, D D, Snell, C, Liu, C, Gleeson, F V, Harris, A L, Lord, S R, McGowan, D R
Format Journal Article
LanguageEnglish
Published England 01.03.2022
Subjects
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carboxylic Acids - administration & dosage
Carboxylic Acids - pharmacokinetics
Cyclobutanes - administration & dosage
Cyclobutanes - pharmacokinetics
Female
Humans
Metformin - therapeutic use
Neoplasm Grading
Positron Emission Tomography Computed Tomography
Sensitivity and Specificity
Treatment Outcome
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Summary:F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades. Thirty-nine patients with pathologically proven breast cancer underwent 20-min dynamic PET/computed tomography imaging following the administration of F-fluciclovine. Uptake into primary breast tumours was evaluated using one- and two-tissue reversible compartmental kinetic models and static parameters. A reversible one-tissue compartment model was shown to best describe tracer uptake in breast cancer. No significant differences were seen in kinetic or static parameters for different tumour receptor subtypes or grades. Kinetic and static parameters showed a good correlation. F-fluciclovine has potential in the imaging of primary breast cancer, but kinetic analysis may not have additional value over static measures of tracer uptake. NCT03036943.
ISSN:1532-1827