Screening of biological properties of Mo V 2 O 2 S 2 - and Mo V 2 O 4 -based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass

• Published in: Journal of inorganic biochemistry Vol. 226; p. 111627
• Main Authors: Fuior, Arcadie, Hijazi, Akram, Garbuz, Olga, Bulimaga, Valentina, Zosim, Liliana, Cebotari, Diana, Haouas, Mohamed, Toderaş, Ion, Gulea, Aurelian, Floquet, Sébastien
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Biomass; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Humans; Molybdenum - chemistry; Spirulina - growth & development; Antibiotic activity; Spirulina platensis; Cluster; Cytotoxicity; Molybdenum; Complex
• ISSN: 1873-3344

This paper deals with the biological potential of coordination compounds based on binuclear core [Mo O E ] (E = O or S) coordinated with commercially available ligands such as oxalates (Ox ), L-cysteine (L-cys ), L-histidine (L-his ), Iminodiacetate (IDA ), Nitrilotriacetate (HNTA or NTA ) or ethylenediamine tetraacetate (EDTA ) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo O E (L-cys) ] complexes stand out as powerful antioxidant, whereas [Mo O E (EDTA)] associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.