Risk factors for left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients with low CHA 2 DS 2 -VASc score

• Published in: Journal of thrombosis and thrombolysis Vol. 53; no. 2; p. 523
• Main Authors: Chen, Jindong, Zhou, Mengmeng, Wang, Hao, Zheng, Zhihuang, Rong, Wenwen, He, Ben, Zhao, Liang
• Format: Journal Article
• Language: English
• Published: Netherlands 01.02.2022
• Subjects: Spontaneous echo contrast; CHA2DS2-VASc score; Non-valvular atrial fibrillation; Left atrial thrombus; Risk factors
• ISSN: 1573-742X

Risk factors of left atrial thrombus (LAT) or spontaneous echo contrast (LASEC) in non-valvular atrial fibrillation (NVAF) had been reported. However, information in the subgroup of NVAF patients with low CHA DS -VASc scores was limited. Here, we evaluated the risk factors of LAT/LASEC in NVAF patients with low CHA DS -VASc scores. Transesophageal echocardiography (TEE) file of NVAF patients with low CHA DS -VASc scores was reviewed (between June 2009 and Feb 2019) in this retrospective observational study. Binary logistic regression analysis was performed to identify risk factors other than the CHA DS -VASc score. Propensity score matching (PSM) was used to further evaluate independent risk markers for LAT/LASEC. The newly discovered factors were added to the CHA DS -VASc score, and receiver operating characteristic analysis was used to evaluate the ability of the model to predict LAT/LASEC. TEE files of 3056 NVAF patients with low CHA DS -VASc scores were reviewed. Regression analysis revealed elevated fibrinogen and enlarged left atrium (LA) were risk factors for LAT/LASEC. Further PSM analysis confirmed that elevated fibrinogen and enlarged LA were independent risk factors for LAT/LASEC. After including fibrinogen and left atrial diameter (LAD), the CHA DS -VASc score was more accurate for LAT/LASEC prediction in NVAF patients with low CHA DS -VASc scores (area under the curve difference is 0.241, 95% confidence interval (CI) 0.188-0.294, Z = 8.890, P < 0.0001). Elevated fibrinogen and enlarged LA were independent risk factors for LAT/LASEC in NVAF patients with low CHA DS -VASc scores. Taking fibrinogen and LAD into consideration may help improve LAT/LASEC risk evaluation, which warrants further validation studies.