An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and other Conditions

Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked na...

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Published inCurrent topics in medicinal chemistry Vol. 21; no. 22; p. 1977
Main Authors da S M Forezi, Luana, de Souza, Acácio S, Lima, Carolina G S, Borges, Amanda A, Ferreira, Patricia G, Barros, Marcela C P, Futuro, Debora O, de C da Silva, Fernando, Ferreira, Vitor F
Format Journal Article
LanguageEnglish
Published United Arab Emirates 2021
Subjects
Animals
Communicable Diseases - drug therapy
Humans
Naphthoquinones - chemical synthesis
Naphthoquinones - pharmacology
Naphthoquinones - therapeutic use
Medicinal chemistry
Biological activities
Infectious diseases
Quinone
Synthetic methods
Naphthalenedione
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Summary:Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked naphthoquinone units. In the last few years, several synthetic approaches toward such valuable compounds have been described, as well as their evaluation against numerous important biological targets. In this review, we provide a thorough discussion on the various synthetic methods reported for the synthesis of bis(naphthoquinone) analogues, also highlighting the biological activities of these substances.
ISSN:1873-4294