Eosinophils increase macrophage ability to control intracellular Leishmania amazonensis infection via PGD 2 paracrine activity in vitro

Clinical and experimental studies have described eosinophil infiltration in Leishmania amazonensis infection sites, positioning eosinophils strategically adjacent to the protozoan-infected macrophages in cutaneous leishmaniasis. Here, by co-culturing mouse eosinophils with L. amazonensis-infected ma...

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Bibliographic Details
Published inCellular immunology Vol. 363; p. 104316
Main Authors da Silva Marques, Patrícia, da Fonseca-Martins, Alessandra M, Carneiro, Monique Pacheco Duarte, Amorim, Natália R T, de Pão, Camila R Rodrigues, Canetti, Claudio, Diaz, Bruno L, de Matos Guedes, Herbert L, Bandeira-Melo, Christianne
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.2021
Subjects
Prostaglandin D
Eosinophil
L. amazonensis
Macrophage
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Summary:Clinical and experimental studies have described eosinophil infiltration in Leishmania amazonensis infection sites, positioning eosinophils strategically adjacent to the protozoan-infected macrophages in cutaneous leishmaniasis. Here, by co-culturing mouse eosinophils with L. amazonensis-infected macrophages, we studied the impact of eosinophils on macrophage ability to regulate intracellular L. amazonensis infection. Eosinophils prevented the increase in amastigote numbers within macrophages by a mechanism dependent on a paracrine activity mediated by eosinophil-derived prostaglandin (PG) D acting on DP2 receptors. Exogenous PGD mimicked eosinophil-mediated effect on managing L. amazonensis intracellular infection by macrophages and therefore may function as a complementary tool for therapeutic intervention in L. amazonensis-driven cutaneous leishmaniasis.
ISSN:1090-2163