Low vitamin D status is associated with anaemia in hospitalised cats

The major physiological role of vitamin D has traditionally been considered to be the regulation of calcium homeostasis and maintenance of skeletal health. However, there is increasing evidence that vitamin D influences a wider range of physiological processes including erythropoiesis. Vitamin D (25...

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Published inVeterinary record Vol. 187; no. 1; p. e6
Main Authors Titmarsh, Helen Faye, Woods, Glynn Alan, Cartwright, Jennifer A, Kilpatrick, Scott, Gaylor, Donna, Berry, Jaqueline, Gow, Adam, Bommer, Nick X, Gunn-Moore, Danielle, Handel, Ian, Mellanby, Richard J
Format Journal Article
LanguageEnglish
Published England 01.07.2020
Subjects
Anemia - blood
Anemia - therapy
Anemia - veterinary
Animals
Cat Diseases - blood
Cat Diseases - therapy
Cats
Erythrocyte Count - veterinary
Female
Hospitalization - statistics & numerical data
Male
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - therapy
Vitamin D Deficiency - veterinary
anaemia
cats
vitamin D
hospitalised
vitamin deficiency
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Summary:The major physiological role of vitamin D has traditionally been considered to be the regulation of calcium homeostasis and maintenance of skeletal health. However, there is increasing evidence that vitamin D influences a wider range of physiological processes including erythropoiesis. Vitamin D (25-hydroxyvitamin D, 25(OH)D) deficiency concentrations have been associated with anaemia in human beings. In contrast, the relationship between vitamin D status and erythropoiesis has not been investigated in cats. Clinical records of cats consecutively presenting between November 2013 and February 2015 were reviewed. For each cat, data including sex, age, breed, serum albumin and creatinine concentrations, and appetite scores were extracted. A multivariable linear regression model was constructed to examine the relationship between 25(OH)D concentrations and these variables. Cats with anaemia had significantly lower 25(OH)D concentrations (median 49.5 nmol/l, n=31) than cats with packed cell volume above the lower limit of the reference range (median 109.0 nmol/l, n=130) (P<0.001). A binary logistic regression found that red blood cell count and mean corpuscular volume were negatively correlated with serum 25(OH)D concentrations (P<0.001 and P=0.007, respectively). Vitamin D (25(OH)D) concentration is positively associated with red blood cell count and mean corpuscular volume in cats with a wide range of different illnesses.
ISSN:2042-7670