Adrenal Histoplasmosis in Immunocompetent Individuals a Case Series from the North-Western Part of India, Rajasthan Province: An Emerging Endemic Focus

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum and very few cases reported from North-West India. Adrenal histoplasmosis is an even more uncommon mycotic disease. We describe five immunocompetent men with adrenal histoplasmosis presenting with constitutional symptoms. Four pat...

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Published inIndian journal of medical microbiology Vol. 38; no. 3-4; p. 485
Main Authors Sharma, Balram, Nehara, Hardeva Ram, Bhavi, Vijay Kumar, Maan, Pratibha, Saran, Sanjay
Format Journal Article
LanguageEnglish
Published United States 01.07.2020
Subjects
immunocompetent
Rajasthan
Adrenal histoplasma
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Summary:Histoplasmosis is a fungal infection caused by Histoplasma capsulatum and very few cases reported from North-West India. Adrenal histoplasmosis is an even more uncommon mycotic disease. We describe five immunocompetent men with adrenal histoplasmosis presenting with constitutional symptoms. Four patients had bilateral adrenal involvement, whereas one had unilateral adrenal mass. Three patients had adrenal insufficiency at presentation and the other two developed adrenal insufficiencies during follow-up. All the patients received amphotericin B and itraconazole treatment which led to symptomatic improvement but adrenal insufficiency persisted in all patients at the end of the follow-up.
ISSN:1998-3646