The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients

• Published in: Human antibodies Vol. 29; no. 1; p. 95
• Main Authors: Khazaei, Hossein Ali, Naderi, Majid, Aliabad, Ghasem Miri, Tabatabaei, Seyed Mohammad Nasiraldin, Alidadi, Ali, Moulaei, Nezar Ali, Safdari, Mohammad, Nahvi, Hedayatollah, Cohan, Nader, Dehghan, Javid, Mehraban, Ahmad, Jalili, Arman, Khazaei, Amin, Khazaei, Ehsan, Khazaei, Bahman, Khazaei, Behnam, Rezaei, Nima, Salarzaie, Morteza, Soleimani, Gholamreza
• Format: Journal Article
• Language: English
• Published: Netherlands 2021
• Subjects: CD4/CD8 ratio; hemophilia disease
• ISSN: 1875-869X

The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity. Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean ± SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. Among 80 type A hemophilia patients, 66 (82.5%) were male. The mean age was 15 ± 3.51 years. 12 (15%) of them were suffering from mild disease and 68 (85%) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 ± 0.78. The correlation between this ration and disease severity was 0.019. The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender.