18 F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology

In mouse models of dengue virus (DENV) infection, F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of F-FDG PET to study the pathogenesis of inflammation and disease activi...

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Bibliographic Details
Published inAntiviral research Vol. 185; p. 104991
Main Authors Kalimuddin, Shirin, Xie, Wanying, Watanabe, Satoru, Tham, Jing Yang, Sam, Huizhen, Chan, Kitti Wing Ki, Yap, Tiang Siew, Totman, John J, Chacko, Ann-Marie, Vasudevan, Subhash G, Low, Jenny G
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2021
Subjects
FDG-PET
Pathogenesis
Dengue
Inflammation
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Summary:In mouse models of dengue virus (DENV) infection, F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.
ISSN:1872-9096