Pharmacogenomics : a toolbox to improve drug prescription

As a result of advances in pharmacogenomics (PGx), the paradigm that a single dose of a drug is extrapolated to an entire population is set to change. Personalising drug prescriptions according to individual genomic determinants would make it possible to increase the effectiveness and tolerance of t...

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Bibliographic Details
Published inRevue médicale suisse Vol. 16; no. 716; p. 2259
Main Authors Jaccard, Evrim, Redin, Claire, Girardin, François, Waeber, Gérard, Fellay, Jacques, Vollenweider, Peter
Format Journal Article
LanguageFrench
Published Switzerland 25.11.2020
Subjects
Drug Prescriptions - standards
Genomics
Humans
Pharmacogenetics
Physicians
Precision Medicine - methods
Switzerland
Switzerland
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Summary:As a result of advances in pharmacogenomics (PGx), the paradigm that a single dose of a drug is extrapolated to an entire population is set to change. Personalising drug prescriptions according to individual genomic determinants would make it possible to increase the effectiveness and tolerance of treatments. In Switzerland, any doctor can prescribe validated PGx tests for five actionable drugs : abacavir, carbamazepine, thiopurines [azathioprine], fluoropyrimidines [5-FU, capecitabine] and irinotecan. Such an approach presupposes that PGx data are shared with trained clinicians and that prescribing aids can guide them.
ISSN:1660-9379