Value of exchange transfusion in the treatment of severe malaria (apropos of 5 cases)

Five imported falciparum malaria cases with severe evolution are reported. Treatment associated a blood exchange transfusion and an antimalaria chemotherapy (mefloquine in three patients and quinine in two patients). All patients were successfully cured despite of serious visceral complications occu...

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Bibliographic Details
Published inBulletin de la Societe de pathologie exotique et de ses filiales Vol. 80; no. 3 Pt 2; p. 561
Main Authors Lataste, P, Soubiran, G, Nlend, A, Le Bras, M, Roue, R, Wone, C, Ragnaud, J C, Buil, A, Briand, M C, Ripert, C
Format Journal Article
LanguageFrench
Published France 1987
Subjects
Adult
Animals
Antimalarials - therapeutic use
Combined Modality Therapy
Exchange Transfusion, Whole Blood
Female
Humans
Malaria - drug therapy
Malaria - therapy
Male
Mefloquine
Middle Aged
Plasmodium falciparum
Quinine - therapeutic use
Quinolines - therapeutic use
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Summary:Five imported falciparum malaria cases with severe evolution are reported. Treatment associated a blood exchange transfusion and an antimalaria chemotherapy (mefloquine in three patients and quinine in two patients). All patients were successfully cured despite of serious visceral complications occurring in two patients (pulmonary and cerebral oedema). Technical management of treatment is detailed. Exchange transfusion should be considered in falciparum malaria when parasitaemia overcomes 20% and when serious visceral impairment, hemolysis or consumption coagulopathy are occurring.