18 F-FDG PET/CT versus anatomic imaging for evaluating disease extent and clinical trial eligibility in Erdheim-Chester disease: results from 50 patients in a registry study

• Published in: European journal of nuclear medicine and molecular imaging Vol. 48; no. 4; p. 1154
• Main Authors: Kirchner, Julian, Hatzoglou, Vaios, Buthorn, Justin B, Bossert, Dana, Sigler, Allison M, Reiner, Anne S, Ulaner, Gary A, Diamond, Eli L
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2021
• Subjects: 18F-FDG PET/CT; RECIST; ECD; Erdheim-Chester disease; Modified PERCIST; Trial eligibility
• ISSN: 1619-7089

The aim of this study was to [1] characterize distribution of Erdheim-Chester Disease (ECD) by F-FDG PET/CT and [2] determine the utility of metabolic ( F-FDG PET/CT) imaging versus anatomic imaging (CT or MRI) in evaluating ECD patients for clinical trial eligibility. F-FDG PET/CT and corresponding CT or MRI studies for ECD patients enrolled in a prospective registry study were reviewed. Sites of disease were classified as [1] detectable by F-FDG PET only, CT/MRI only, or both and as [2] measurable by modified PERCIST (mPERCIST) only, RECIST only, or both. Descriptive analysis was performed and paired t test for between-group comparisons. Fifty patients were included (mean age 51.5 years; range 18-70 years). Three hundred thirty-three disease sites were detected among all imaging modalities, 188 (56%) by both F-FDG PET and CT/MRI, 67 (20%) by F-FDG PET only, 75 (23%) by MRI brain only, and 3 (1%) by CT only. Of 178 disease sites measurable by mPERCIST or RECIST, 40 (22%) were measurable by both criteria, 136 (76%) by mPERCIST only, and 2 (1%) by RECIST only. On the patient level, 17 (34%) had mPERCIST and RECIST measurable disease, 30 (60%) had mPERCIST measurable disease only, and 0 had RECIST measurable disease only (p < 0.0001). Compared with anatomic imaging, F-FDG PET/CT augments evaluation of disease extent in ECD and increases identification of disease sites measurable by formal response criteria and therefore eligibility for clinical trials. Complementary organ-specific anatomic imaging offers the capacity to characterize sites of disease in greater anatomic detail. ClinicalTrials.gov Identifier: NCT03329274.