Extension of TORCH spectrum in ophthalmology: congenital Zika, case report

Zika is a flavivirus that can be transmitted transplacentally. Eye abnormalities have been reported in 70% of Zika cases, and 41.7% of them can occur in the absence of microcephaly. The most common ocular abnormalities are macular atrophy, optic atrophy and chorioretinal coloboma. The objective was...

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Published inRevista medica del Instituto Mexicano del Seguro Social Vol. 57; no. 6; p. 395
Main Authors Pando-Cifuentes, Alejandra, Cortés-González, Vianney, Berrones-Medina, David, Villanueva-Mendoza, Cristina
Format Journal Article
LanguageSpanish
Published Mexico 30.12.2019
Subjects
Delayed Diagnosis
Developmental Disabilities - diagnosis
Exotropia - diagnosis
Female
Humans
Infant
Microcephaly - diagnosis
Optic Atrophy - diagnosis
Optic Nerve - abnormalities
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Trimester, First
Skin Abnormalities - diagnosis
Zika Virus Infection - congenital
Zika Virus Infection - diagnosis
Zika Virus Infection - transmission
Macula Lutea
abnormalities
Optic Nerve
Zika Virus Infection
Microcephaly
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Summary:Zika is a flavivirus that can be transmitted transplacentally. Eye abnormalities have been reported in 70% of Zika cases, and 41.7% of them can occur in the absence of microcephaly. The most common ocular abnormalities are macular atrophy, optic atrophy and chorioretinal coloboma. The objective was to report the case of eye disorders associated with Zika, acquired transplacentally, despite negative results for TORCH, and serology and PCR analyses for Zika. 9-month-old female patient, born in Chiapas, Mexico, brought to an ophthalmologic evaluation because she did not follow objects. As family background patient's mother had Zika, confirmed serologically at 9 weeks gestation. Physical examination revealed microcephaly, redundant skin on neck, joint stiffness and delayed psychomotor development. Ophthalmological examination revealed in right eye atrophy of the optic nerve, and left eye with exotropia, macular scar and optic nerve aplasia. TORCH profile and serology and PCR for Zika were negative. Despite the negative serology for Zika, given the history of pregnancy and the pre and post-natal clinical manifestations, diagnosis of embryopathy secondary to Zika infection with optic nerve aplasia, chorioretinal atrophy, macular scar, microcephaly and global neurodevelopmental delay was made.
ISSN:2448-5667