Cryptococcosis in non-human immunodeficiency virus-infected patients: A clinical dilemma and diagnostic enigma

Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly tho...

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Published inIndian journal of medical microbiology Vol. 38; no. 2; p. 229
Main Authors Paul, Manisha, Bhatia, Mohit, Rohilla, Ranjana, Sasirekha, Udayakumar, Kaistha, Neelam
Format Journal Article
LanguageEnglish
Published United States 01.04.2020
Subjects
Adult
Antifungal Agents - therapeutic use
Child
Cryptococcosis - diagnosis
Cryptococcosis - drug therapy
Cryptococcosis - microbiology
Cryptococcus - growth & development
Cryptococcus - isolation & purification
Female
Humans
Male
Middle Aged
Cryptococcosis
human immunodeficiency virus
non-immunocompromised
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Summary:Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly those who are infected with human immunodeficiency virus. However, this infection has also been reported in phenotypically 'normal' or otherwise clinically non-immunocompromised patients. The seemingly mysterious nature of this potentially fatal illness has always kept clinicians and diagnosticians in a dilemma. This case series reiterates this perspective.
ISSN:1998-3646