CMR T 1 mapping and strain analysis in idiopathic inflammatory myopathy: evaluation in patients with negative late gadolinium enhancement and preserved ejection fraction

• Published in: European radiology Vol. 31; no. 3; p. 1206
• Main Authors: Zhao, Peijun, Huang, Lu, Ran, Lingping, Tang, Dazhong, Zhou, Xiaoyue, Xia, Liming
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2021
• Subjects: Contrast Media; Female; Fibrosis; Gadolinium; Humans; Magnetic Resonance Imaging, Cine; Magnetic Resonance Spectroscopy; Myocardium - pathology; Myositis - diagnostic imaging; Myositis - pathology; Predictive Value of Tests; Prospective Studies; Stroke Volume; Ventricular Function, Left; Magnetic resonance imaging; Fibrosis; Idiopathic inflammatory myopathy; Myocardium
• ISSN: 1432-1084

To investigate whether cardiovascular magnetic resonance (CMR) T mapping and strain parameters can detect early histological and functional myocardial changes in idiopathic inflammatory myopathy (IIM) with negative late gadolinium enhancement (LGE) and preserved ejection fraction. Thirty consecutive patients with IIM (41.5 ± 15.4 years, 24 females) who did not have LGE or reduced left ventricular ejection fraction (LVEF) and 30 age- and gender-matched healthy controls (40.6 ± 14.2 years, 20 females) were recruited. Patients with IIM were further classified into two subgroups according to high-sensitivity cardiac troponin I (hs-cTnI) values: elevated hs-cTnI subgroup (n = 10) and normal hs-cTnI subgroup (n = 20). Myocardial native T values, extracellular volume (ECV) fractions, and strain parameters were analyzed in patients with IIM and healthy controls. Compared with healthy controls, patients with IIM had significantly prolonged native T values and increased ECV in each LV segment (p < 0.05). In further subgroup analysis, LV mid-slice native T values had the most power to discriminate between patients with elevated hs-cTnI and healthy controls (area under the curve = 0.92). There was no significant difference of global LV strain or strain rates between IIM patients and controls. Diffuse interstitial fibrosis can be detected by CMR T mapping in patients with IIM who do not have LGE or reduced LVEF or elevated hs-cTnI, and it may be a promising method for screening subclinical cardiac involvement in IIM. • Myocardial abnormality in IIM is often subclinical and leads to poor prognosis. • Conventional CMR parameters have limitations in early detection of cardiac function and tissue changes. • CMR T mapping techniques and myocardial strain analysis have the potential to provide detailed information on cardiac histology and function.