Evaluation of cytotoxic, immunomodulatory effects, antimicrobial activities and phytochemical constituents from various extracts of Passiflora edulis F. flavicarpa (Passifloraceae)

• Published in: Natural product research p. 1
• Main Authors: de Sousa, Georon Ferreira, Santos, Dayane Kelly Dias do Nascimento, da Silva, Ricardo Sérgio, Barros, Bárbara Rafaela da Silva, da Cruz-Filho, Iranildo José, Ramos, Bárbara de Azevedo, da Silva, Túlio Diego, da Silva, Pérsio Alexandre, de Lima-Neto, Reginaldo Gonçalves, de Gusmão, Norma Buarque, do Nascimento, Marcia Silva, Lagos de Melo, Cristiane Moutinho
• Format: Journal Article
• Language: English
• Published: England 07.08.2020
• Subjects: P. edulis; Anti-inflammatory profile; phenolic compounds; antifungal activity
• ISSN: 1478-6427

The leaves of were subjected to physicochemical analysis, such as ion content, extractives, and structural molecules. The hexanic, ethanolic and ethyl acetate extracts were submitted to phytochemical analyzes by GC-MS, HPLC-MS, and spectrophotometry. In addition, antioxidant (DPPH, ABTS and TAA methods) potential, antimicrobial (MIC method) action, cytotoxicity and immunostimulant activity (flow cytometry analysis) were performed. The extracts showed a moderate antioxidant capacity and revealed the presence of several metabolites, mainly phenols, such as caffeic acid, p-coumaric acid and luteolin. The ethyl acetate and ethanolic extracts showed antifungal activity. In addition, the extracts did not affect splenocytes viability at 12.5 μg/mL and promoted the production of IL-6, IL-10, IL-17 and TNF-α cytokines. extracts showed antifungal and antioxidant activity and were able to induce immunostimulatory action in splenocyte cultures .