Role of 68 Ga-DOTATATE PET/CT in a Case of SDHB -Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide

We describe an unusual case of a 42-year-old female with an unresectable succinate dehydrogenase subunit B ( -related pterygopalatine fossa paraganglioma. She underwent somatostatin receptor imaging with Ga-DOTA(0)-Tyr(3)-octreotate ( Ga-DOTATATE) positron emission tomography/computed tomography (PE...

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Bibliographic Details
Published inNuclear medicine and molecular imaging Vol. 54; no. 1; p. 48
Main Authors Jha, Abhishek, Patel, Mayank, Baker, Eva, Gonzales, Melissa K, Ling, Alexander, Millo, Corina, Knue, Marianne, Civelek, Ali Cahid, Pacak, Karel
Format Journal Article
LanguageEnglish
Published Germany 01.02.2020
Subjects
PRRT
Paraganglioma
SSTR
177Lu-DOTATATE
Octreotide
68Ga-DOTATATE PET/CT
SDHB
Somatostatin analog
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Summary:We describe an unusual case of a 42-year-old female with an unresectable succinate dehydrogenase subunit B ( -related pterygopalatine fossa paraganglioma. She underwent somatostatin receptor imaging with Ga-DOTA(0)-Tyr(3)-octreotate ( Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed uptake in the above mentioned tumor. Hence, the patient was started on octreotide, a cold somatostatin analog, and responded with tumor stabilization and improvement of clinical symptoms for 36 months since initiation of octreotide therapy. This case demonstrates the role of Ga-DOTATATE PET/CT in diagnostic localization and its subsequent role in treatment using cold somatostatin analog as a potential choice of therapy in the management of paraganglioma in an unusual location with limited therapeutic options.
ISSN:1869-3474