Responsive functionalized MoSe 2 nanosystem for highly efficient synergistic therapy of breast cancer

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 189; p. 110820
• Main Authors: Liu, Yanan, Wei, Chunfang, Lin, Ange, Pan, Jiali, Chen, Xu, Zhu, Xufeng, Gong, Youcong, Yuan, Guanglong, Chen, Lanmei, Liu, Jie, Luo, Zhaohui
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2020
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Carriers - chemistry; Drug Carriers - pharmacology; Drug Screening Assays, Antitumor; Female; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacology; Indoles - chemistry; Indoles - pharmacology; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Mice; Molybdenum - chemistry; Molybdenum - pharmacology; Nanoparticles - chemistry; Particle Size; Photochemotherapy; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Polymers - chemistry; Polymers - pharmacology; Selenium Compounds - chemistry; Selenium Compounds - pharmacology; Surface Properties; Photothermal therapy; Molybdenum selenide; Photodynamic therapy; Photostability; Multimodal imaging; Breast cancer
• ISSN: 1873-4367

The photothermal/photodynamic synergistic therapy is a promising tumor treatment, but developing nanosystems that achieve synchronous photothermal/photodynamic functions is still quite challenging. Here, we use a simple method to synthesize molybdenum selenide nanoparticles (MoSe NPs) with a photothermal effect as a carrier, and load a photosensitizer ICG to form a nanosystem (MoSe @ICG-PDA-HA)with dual photothermal/photodynamic functions under near-infrared irradiation. In addition, the surface modification of the nanosystem with acid-responsive release polydopamine (PDA) and tumor-targeted hyaluronic acid (HA) enhanced the stability of the photosensitizer ICG and the accumulation of ICG at tumor sites. The multicellular sphere assay simulated solid tumors and demonstrated that MoSe @ICG-PDA-HA could significantly inhibit the 4T1 cell growth. The anti-tumor experiments in tumor-bearing mice showed that MoSe @ICG-PDA-HA not only significantly inhibited the growth of 4T1 subcutaneous tumors, but also inhibited their metastasis. This study presented a nanosystem that could improve the photostability of optical materials and enhance the photothermal/photodynamic synergy effect, providing a new idea for finding a way to effectively treat breast cancer.