Transcriptome-wide map of m 6 A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension

Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m A-modified. The abundance of circRNAs was influenced by m A. Furthermore, the significance of m A circRNAs has...

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Published inBMC genomics Vol. 21; no. 1; p. 39
Main Authors Su, Hua, Wang, Guowen, Wu, Lingfang, Ma, Xiuqing, Ying, Kejing, Zhang, Ruifeng
Format Journal Article
LanguageEnglish
Published England 13.01.2020
Subjects
m6A circTmtc3
m6A circXpo6
Hypoxia mediated pulmonary hypertension
m6A circRNAs
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Summary:Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m A-modified. The abundance of circRNAs was influenced by m A. Furthermore, the significance of m A circRNAs has not been elucidated in HPH yet. Here we aim to investigate the transcriptome-wide map of m A circRNAs in HPH. Differentially expressed m A abundance was detected in lungs of HPH rats. M A abundance in circRNAs was significantly reduced in hypoxia in vitro. M A circRNAs were mainly from protein-coding genes spanned single exons in control and HPH groups. Moreover, m A influenced the circRNA-miRNA-mRNA co-expression network in hypoxia. M A circXpo6 and m A circTmtc3 were firstly identified to be downregulated in HPH. Our study firstly identified the transcriptome-wide map of m A circRNAs in HPH. M A can influence circRNA-miRNA-mRNA network. Furthermore, we firstly identified two HPH-associated m A circRNAs: circXpo6 and circTmtc3. However, the clinical significance of m A circRNAs for HPH should be further validated.
ISSN:1471-2164