Experimental pneumonia caused by an association of H. influenzae and the influenza virus

Experiments in 400 non-inbred white mice indicated that the association of influenza virus A2 Hong Kong with H. influenzae enhanced the pathogenic action of the causative agents and led to the unfavorable clinical outcome only in those cases when these agents penetrated the body simultaneously, or w...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 8; p. 94
Main Authors Shapiro, A V, Kuz'menkova, L V, Mochalin, I A, Gorin, V I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.08.1979
Subjects
Animals
Haemophilus Infections - etiology
Haemophilus Infections - microbiology
Haemophilus influenzae
Hong Kong
Mice
Orthomyxoviridae Infections - etiology
Orthomyxoviridae Infections - microbiology
Pneumonia - etiology
Pneumonia - microbiology
Pneumonia, Viral - etiology
Pneumonia, Viral - microbiology
Time Factors
Hong Kong
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Summary:Experiments in 400 non-inbred white mice indicated that the association of influenza virus A2 Hong Kong with H. influenzae enhanced the pathogenic action of the causative agents and led to the unfavorable clinical outcome only in those cases when these agents penetrated the body simultaneously, or when viral infection preceded bacterial infection. In those cases when influenza infection appeared in the presence of bacterial infection, the pathological process developed as a monoviral disease. The morphological changes in the lungs of the mice infected with H. influenzae corresponded to lesions caused by influenza virus and were manifested by pronounced hemodynamic disturbances.
ISSN:0372-9311