Antileishmanial activity and immunomodulatory effect of seco subamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)
Visceral leishmaniasis is a complex neglected tropical disease caused by complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodu...
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Published in | The journal of venomous animals and toxins including tropical diseases Vol. 25; p. e20190008 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Brazil
2019
|
Subjects | |
Online Access | Get full text |
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Abstract | Visceral leishmaniasis is a complex neglected tropical disease caused by
complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from
(Lauraceae) was investigated herein
The
-hexane extract from twigs of
were subjected to HPLC/HRESIMS and bioactivity-guided fractionation to afford compounds
and
which were evaluated
against
(
)
and NCTC cells.
The
-hexane extract displayed activity against
(
)
and afforded
linderanolide E (
) and
subamolide A (
), which were effective against
(
)
promastigotes, with IC
values of 57.9 and 24.9 µM, respectively. Compound
was effective against amastigotes (IC
= 10.5 µM) and displayed moderate mammalian cytotoxicity (CC
= 42 µM). The immunomodulatory studies of compound
suggested an anti-inflammatory activity, with suppression of IL-6, IL-10, TNF with lack of nitric oxide.
This study showed the antileishmanial activity of compounds
and
isolated from
. Furthermore, compound
demonstrated an antileishmanial activity towards amastigotes associated to an immunomodulatory effect. |
---|---|
AbstractList | Visceral leishmaniasis is a complex neglected tropical disease caused by
complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from
(Lauraceae) was investigated herein
The
-hexane extract from twigs of
were subjected to HPLC/HRESIMS and bioactivity-guided fractionation to afford compounds
and
which were evaluated
against
(
)
and NCTC cells.
The
-hexane extract displayed activity against
(
)
and afforded
linderanolide E (
) and
subamolide A (
), which were effective against
(
)
promastigotes, with IC
values of 57.9 and 24.9 µM, respectively. Compound
was effective against amastigotes (IC
= 10.5 µM) and displayed moderate mammalian cytotoxicity (CC
= 42 µM). The immunomodulatory studies of compound
suggested an anti-inflammatory activity, with suppression of IL-6, IL-10, TNF with lack of nitric oxide.
This study showed the antileishmanial activity of compounds
and
isolated from
. Furthermore, compound
demonstrated an antileishmanial activity towards amastigotes associated to an immunomodulatory effect. |
Author | Galisteo, Jr, Andrés J Tempone, Andre G da Costa-Silva, Thais A Conserva, Geanne A Alves Lago, João Henrique G |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31467511$$D View this record in MEDLINE/PubMed |
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Keywords | Nectandra oppositifolia Antileishmanial Leishmania (L.) infantum chagasi Secosubamolide Immunomodulatory |
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Title | Antileishmanial activity and immunomodulatory effect of seco subamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae) |
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