Progress in epigenetic modification of mRNA and the function of m6A modification

Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the...

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Published inShengwu gongcheng xuebao Vol. 35; no. 5; p. 775
Main Authors Gan, Haili, Hong, Ling, Yang, Fenglian, Liu, Dingfeng, Jin, Liping, Zheng, Qingliang
Format Journal Article
LanguageChinese
Published China 25.05.2019
Subjects
Adenosine - analogs & derivatives
Adenosine - genetics
Adenosine - metabolism
Cell Differentiation - genetics
Embryonic Development - genetics
Epigenesis, Genetic
Gene Expression Regulation
RNA Processing, Post-Transcriptional
RNA, Messenger - metabolism
N6-methyladenosine (m6A)
cell differentiation
epigenetic modification of mRNA
mRNA metabolism
N1-methyladenosine (m1A)
pseudouridine
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Summary:Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the progress of cells through modulating mRNA metabolism and translation. Other mRNA modifications, including N1-methyladenosine (m¹A), 5-methylcytosine (m⁵C) and pseudouridine, together with m⁶A form the epitranscriptome of mRNA that accurately modulate the mRNA translation. Here we review the types and characteristic of mRNA epigenetic modifications, especially the recent progresses of the function of m⁶A, we also expect the main research direction of m⁶A epigenetic modification in the future.
ISSN:1000-3061