Store-independent Orai1-mediated Ca 2+ entry and cancer
Ca channels play an important role in the development of different types of cancer, and considerable progress has been made to understand the pathophysiological mechanisms underlying the role of Ca influx in the development of different cancer hallmarks. Orai1 is among the most ubiquitous and multif...
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Published in | Cell calcium (Edinburgh) Vol. 80; p. 1 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Ca
channels play an important role in the development of different types of cancer, and considerable progress has been made to understand the pathophysiological mechanisms underlying the role of Ca
influx in the development of different cancer hallmarks. Orai1 is among the most ubiquitous and multifunctional Ca
channels. Orai1 mediates the highly Ca
-selective Ca
release-activated current (I
) and participates in the less Ca
-selective store-operated current (I
), along with STIM1 or STIM1 and TRPC1, respectively. Furthermore, Orai1 contributes to a variety of store-independent Ca
influx mechanisms, including the arachidonate-regulated Ca
current, together with Orai3 and the plasma membrane resident pool of STIM1, as well as the constitutive Ca
influx processes activated by the secretory pathway Ca
-ATPase-2 (SPCA2) or supported by physical and functional interaction with the small conductance Ca
-activated K
channel 3 (SK3) or the voltage-dependent K
10.1 channel. This review summarizes the current knowledge concerning the store-independent mechanisms of Ca
influx activation through Orai1 channels and their role in the development of different cancer features. |
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ISSN: | 1532-1991 |