Scaling of recovery rates influences T-type Ca 2+ channel availability following IPSPs
The excitability of neuronal membranes is crucially modulated by T-type Ca channels ( ) due to their low threshold of activation. inactivates steeply at potentials close to the resting membrane potential. Therefore, the availability of following changes in membrane potential depends on the time cour...
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| Published in | Heliyon Vol. 5; no. 2; p. e01278 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.02.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The excitability of neuronal membranes is crucially modulated by T-type Ca
channels (
) due to their low threshold of activation.
inactivates steeply at potentials close to the resting membrane potential. Therefore, the availability of
following changes in membrane potential depends on the time course of the onset of inactivation as well as on the time course of recovery from inactivation. It was previously shown that the time course of recovery from inactivation depends on the duration of the conditioning pulse in cloned T-type Ca
channel subunits (Ca
3.1-Ca
3.3(Uebachs et al., 2006)). This provides a potential mechanism for an intrinsic form of short term plasticity. Here, we address the question, whether this mechanism results in altered availability of
following physiological changes in membrane potential. We found that the recovery of
during an IPSP depends on the duration of a preceding depolarized period. |
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| ISSN: | 2405-8440 2405-8440 |