Immunochemical analysis in research on antibodies to Streptococcus group A ribosomes

The use of the competitive enzyme immunoassay (EIA) has made it possible to demonstrate that antiserum to the ribosomes of group A streptococcus, type 29 M, contains antibodies to homologous protein M and does not contain antibodies to group A polysaccharide, lipoteichoic acid and peptidoglycan. Rib...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 73
Main Authors Shikhman, A R, Nikolaeva, L V, Kondrakova, O A, Savel'ev, E P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1986
Subjects
Animals
Antibodies, Bacterial - analysis
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins - immunology
Binding Sites, Antibody
Binding, Competitive
Carrier Proteins
Cell Wall - immunology
Cross Reactions
Escherichia coli - immunology
Immunization
Immunodiffusion
Immunoenzyme Techniques
Rabbits
Ribosomes - immunology
Streptococcus pyogenes - immunology
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Summary:The use of the competitive enzyme immunoassay (EIA) has made it possible to demonstrate that antiserum to the ribosomes of group A streptococcus, type 29 M, contains antibodies to homologous protein M and does not contain antibodies to group A polysaccharide, lipoteichoic acid and peptidoglycan. Ribosomal antiserum has been found to bind with the surface of heterologous type M streptococci in EIA, while forming no precipitation lines with heterologous proteins M in the double immunodiffusion test, which indicates that the binding of ribosomal antibodies with the surface of group A streptococcal cells is not type-specific. Antibodies to the ribosomes of group A streptococcus recognize some of the antigenic determinants of E. coli ribosomes.
ISSN:0372-9311