Infectious glomerulonephritis

Infectious glomerulonephritis. Post-infectious or infectious glomerulonephritis (PIGN) represent the most frequent glomerular disease during bacterial infection. Patients, usually young children, with PIGN typically present nephritic syndrome 15 days after an upper respiratory tract infection. In th...

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Bibliographic Details
Published inLa Revue du praticien Vol. 66; no. 10; p. 1115
Main Author François-Pradier, Hélène
Format Magazine Article
LanguageFrench
Published France 01.12.2016
Subjects
Glomérulonéphrites Infectieuses
Néphrologie
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Summary:Infectious glomerulonephritis. Post-infectious or infectious glomerulonephritis (PIGN) represent the most frequent glomerular disease during bacterial infection. Patients, usually young children, with PIGN typically present nephritic syndrome 15 days after an upper respiratory tract infection. In this case renal histology shows exsudative endocapillary proliferation with C3-dominant deposits "hump" shaped in the subepithelial compartment. Renal prognosis was typically favorable. However, nowadays, PIGN is rare and represents less than 1% of kidney biopsies in industrialized countries and usually occurs in immunocompromised hosts (such as patients with cancer, alcoholism, diabetes, elderly patients). Therefore, renal sequels are more frequent. The physiopathology typically involves immune complexes activating the classical complement pathway although alternative complement pathway regulation or abnormal activation were more recently reported. Treatment remains symptomatic.
ISSN:2101-017X